Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition
نویسندگان
چکیده
منابع مشابه
Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal.
Prolyl endopeptidase is a serine proteinase that specifically cleaves peptides on the carboxy side of proline residues. Wilk & Orlowski [(1983) J. Neurochem. 41, 69-75] have shown that benzyloxycarbonyl-prolyl-prolinal (Z-prolyl-prolinal) is a potent inhibitor of prolyl endopeptidase. We show that Z-prolyl-prolinal is a slow-binding inhibitor of mouse brain prolyl endopeptidase with Ki 0.35 +/-...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2019
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2019.07.111